Pharmacovigilance, Materiovigilance, and Haemovigilance together form the backbone of healthcare safety monitoring in India, yet their coverage in undergraduate curriculum remains inconsistent. This prospective cross-sectional study assessed the impact of a short structured educational session on knowledge, attitude, and practice of all three vigilance systems among 200 final-year medical and paramedical students at a tertiary care teaching hospital in Raichur, Karnataka. A validated pre-test/post-test questionnaire was administered before and after a 15-minute seminar; data were analyzed by the Wilcoxon Signed-Rank Test and Chisquare test (SPSS v20.0). The cohort was 56% female, with a mean age of 22.21 ± 1.87 years; pharmacy students made up 79% of participants. Haemovigilance showed the clearest benefit: knowledge improved significantly (p = 0.033) and practice improved highly significantly (p = 0.0002). Pharmacovigilance knowledge edged upward but did not reach significance (p = 0.052), while attitude fell sharply (p = 0.0001). In Materiovigilance, both knowledge (p = 0.035) and attitude (p = 0.032) declined significantly after the session, though all four practice items improved on Chi-square analysis. The declines in attitude scores likely reflect critical recalibration rather than genuine disengagement. A single short seminar can shift knowledge and practice in selected domains, but is insufficient for attitude change across all three. Regular, multi-session, curriculum-integrated vigilance training is needed to build the reporting culture that patient safety requires.