Based on James Phelan’s theory of unreliable narration, this paper analyzes Kazuo Ishiguro’s Never Let Me Go from three dimensions: fact, ethics and knowledge. Centering on Kathy’s misreporting, underreporting, misjudgment, under judgment, misinterpretation and under interpretation, the study explores technological violence, subject disintegration and cognitive confinement behind her retrospective narration. The clone protagonist beautifies memories and adopts institutional discourse to gloss over organ exploitation and surveillance, failing to recognize the systematic oppression embedded in Hailsham. She identifies with the donation system and misjudges self-value, while distorted cognition keeps her from comprehending interpersonal intimacy and the instrumentalized nature of cloned bodies. Her futile pursuit of prototypes further exposes the existential confusion of clones stripped of subjectivity. The novel reveals how power disciplines and deprives marginal lives, and reflects on bioethics and technological development. It also indicates that unilateral narratives constructed by technological systems may mislead public cognition, highlighting the importance of critical awareness and ethical norms for scientific progress.