The main aim of this study is to examine the variables that affect the profitability of GCC banks. The current study provides evidence of important bank-specific variables that have affected GCC banks' profitability by analyzing balanced panel data for 2011 to 2018. Data pertaining was extracted from the annual reports of the selected listed banks. This paper puts into relief the determinants of the profitability of the commercial banking sector of the GCC. The sample compresses 20 GCC banks. The paper examines internal variables (company-level indicators), which include adequacy, liquidity, credit risk, efficiency cost, net credit facilities and bank size. Panel data regression analysis is used for the analysis. Based on the empirical analysis, the cost efficiency, nontraditional revenue sources, and high asset quality are the most significant bank-specific variables, and bank managers that can use them to make future policy decisions. The model generated in the study can explain a greater than 75% change in the total variance of various measures of profitability. This paper adds to the body of knowledge by empirically highlighting the most recent and extensive panel data for the entire banking sector of the GCC. The paper uses a range of independent variables for the internal -specific variables.