The increasing generation of electronic waste (e-waste) presents growing environmental and public health challenges, particularly in countries with limited formal waste-management capacity. In Cameroon, e-waste is increasingly managed through informal activities, while existing systems remain inadequate to address its growing volume and complexity. This article examines Extended Producer Responsibility (EPR) as a policy option for improving e-waste management in Cameroon. Using an analytical approach, it examines the concept, objectives and mechanisms of EPR and assesses its application in selected jurisdictions, including Ireland, Germany, South Africa and Nigeria. The analysis shows that EPR reallocates responsibility for the management of products at the post-consumer stage, placing primary financial and/or operational responsibility on producers, while defining complementary roles for importers, consumers, government authorities and waste management actors. However, the comparative experience also demonstrates that EPR cannot simply be transferred from one jurisdiction to another without considering institutional capacity, market structure, enforcement mechanisms and informal waste-management practices. The article therefore proposes a context-specific and phased approach to EPR in Cameroon, supported by an appropriate legal and institutional framework. Properly designed and enforced, EPR could complement existing waste-management measures and provide a more sustainable framework for e-waste management in Cameroon. The Cameroonian legislator should therefore establish a clear and sufficiently broad legal framework for EPR to ensure its effective application to e-waste management.