The removal of synthetic dyes such as Methylene Blue from aqueous effluents is a critical environmental challenge. This study investigates the efficacy of activated Carbon derived from Pterocarpus santalinoides Fruit as a low-cost and renewable adsorbent of Methylene Blue dye. The Pterocarpus santalinoides activated carbon was analyzed using scanning electron microscopy and Fourier transform infra-red spectroscopy. The Box-Behnken design of response surface methodology (RSM) method was adopted to optimize the adsorption process variables such as contact time (20 – 100 min), adsorbent dose (0.1 – 0.5 g), initial dye concentration (10 – 50 mg/l), and temperature (30 – 60 ℃). The characterization result revealed the good adsorptive properties of the Pterocarpus santalinoides activated carbon. The ANOVA result indicates that quadratic model was reliable for predicting methylene blue removal with R2 of 0.9267 and 0.9618 for adsorption capacity. The optimum condition for the maximum removal efficiency of 95.90 % and adsorption capacity of 5.70 mg/g were achieved at contact time (56.33 min), adsorbent dose (0.43 g), MB concentration (36.26 mg/l) and temperature (55.91 ℃). Both Henry and Langmuir isotherms were well fitted to the adsorption data. The adsorption kinetics was best described by the Psuedo–second order model indicating a chemisorption-dominated process. Equilibrium Isotherm data showed a high correlation with the Langmuir model suggesting a monolayer adsorption on a homogeneous surface. This study successfully demonstrated the efficiency of Box Behnken Design of Response Surface Methodology (BBD – RSM) as a powerful tool for modeling and optimizing the adsorption process, providing a clear path-way for maximizing the efficiency of Pterocarpus santalinoides based activated Carbon for dye wastewater treatment and environmental remediation.