Background: Burnout is a significant occupational phenomenon, particularly prevalent among healthcare professionals due to the demanding and emotionally taxing nature of their work. The World Health Organization (2019) officially recognized burnout as a syndrome resulting from chronic workplace stress that has not been successfully managed. It is characterized by emotional exhaustion, depersonalization, and a reduced sense of personal accomplishment (Maslach & Jackson, 1981). In the Kingdom of Saudi Arabia, studies have indicated alarmingly high levels of burnout among nurses across various clinical settings. A study by Alenezi et al., (2019) found that approximately 62% of nurses in Saudi hospitals experience moderate to high levels of burnout. This issue is particularly concerning in pediatric and maternity settings, where emotional demands are intensified by the vulnerability of the patient population and the expectations of families. Several factors have been identified as contributing to nurse burnout in these settings, including long working hours, staff shortages, high patient loads, shift work, and inadequate managerial or emotional support (Al-Turki et al., 2010; Chemali et al., 2019). These pressures are often exacerbated during the winter season, which is associated with higher pediatric admission rates due to seasonal illnesses, resulting in increased stress and workload for nurses (Almutairi et al., 2021). Objective: This study aims to assess the prevalence of burnout among pediatric nurses working in Maternity and Children Hospital in Dammam during the winter season. It also seeks to identify the main risk factors contributing to burnout and to explore the coping strategies used by nurses. Methods: A cross-sectional study was conducted using a self-administered questionnaire based on the Copenhagen Burnout Inventory (CBI). Which defined as a free and validated tool developed to measure burnout in different domains of life particularly among healthcare workers (Kristensen et al., 2005). The CBI consists of three sub-scales: personal burnout, work-related burnout, and patient-related burnout. The survey was distributed to approximately 80 pediatric nurses working in the Pediatric Emergency Room (PER) and Pediatric Medical Ward at a Maternity and Children Hospital. The sample size was calculated using Slovin’s formula to ensure adequate representation. Data were analyzed using descriptive and inferential statistics to assess burnout levels and identify associated risk factors. Results: The findings indicated high levels of burnout among pediatric nurses across all three CBI domains. The highest scores were observed in the work-related and patientrelated burnout sub-scales, reflecting the demanding nature of pediatric care. The most prominent contributing factors were excessive workload and insufficient managerial support. Nurses reported several coping mechanisms, including peer support, relaxation and mindfulness techniques, and the expressed need for more qualified pediatric staff to distribute the workload more evenly. Conclusion: Burnout among pediatric nurses in this hospital is alarmingly high, particularly during the winter season. Addressing key risk factors and enhancing coping strategies is essential to improving nurse well-being and ensuring high-quality patient care.