Background: Sterilization is a fundamental component of infection control in dental practice, ensuring the safety of both patients and healthcare professionals. However, conventional sterilization procedures are often associated with considerable energy consumption, water usage, and the generation of biomedical and plastic waste. In recent years, increasing attention has been directed toward environmentally sustainable healthcare practices, leading to the adoption of eco-friendly sterilization approaches in dental offices across the United States. Objective: This review aims to highlight current trends in eco-friendly sterilization practices in U.S. dental offices and discuss their potential benefits, challenges, and future implications for sustainable dental care. Discussion: Recent developments in sustainable sterilization include the use of energy-efficient autoclaves, reusable sterilization containers, environmentally safer disinfectants, digital sterilization monitoring systems, and resource-conserving strategies. These innovations seek to reduce the environmental footprint of dental practices while maintaining high standards of infection prevention and regulatory compliance. In addition to environmental benefits, eco-friendly sterilization measures may contribute to long-term cost savings, improved workplace safety, and enhanced patient perception of dental services. Nevertheless, widespread implementation remains influenced by several factors, including financial investment, limited awareness, staff training requirements, and concerns regarding the effectiveness and standardization of certain sustainable alternatives. Conclusion: Eco-friendly sterilization practices represent an important advancement toward sustainable dentistry. Continued technological innovation, professional education, and institutional support are essential to encourage broader adoption of environmentally responsible sterilization methods while preserving the effectiveness of infection control protocols in modern dental offices.