Mercuric chloride is highly toxic and known to cause significant liver and kidney damage through degeneration and inflammation of the tissues. Sarcocephalus latifolius is a medicinal plant traditionally used for its antioxidant and therapeutic properties. This study investigates the protective effects of Sarcocephalus latifolius on mercuric chloride-induced hepatorenal toxicity in albino Wistar rats. The animals were divided into six groups (A-F); A. control group, B. mercuric chloride-induced group, three treatment groups (C, D, E) with two receiving Sarcocephalus latifolius extract and one vitamin C, in addition to mercuric Chloride. The last group (F) received Sarcocephalus latifolius extract only. The result showed that mercuric chloride caused disruption and degeneration of hepatocytes around the central vein while the groups that received Sarcocephalus latifolius showed structural organization relative to that of the control group. Significant improvement was observed in kidney function test (urea and creatinine) when compared to the mercuric chloride treated group. AST and ALT activity showed significant increase but the group (s) treatment with Sarcocephalus latifolius and vitamin C showed significant reduction AST and ALT activity when compared with the mercuric chloride treated group. Histological examination revealed hepatic and glomerular degeneration and disruption in the mercuric chloride treatment group while Sarcocephalus latifolius exhibits potent hepatorenal effects against mercuric chloride-induced hepatorenal damages which could be due to its anti-inflammatory and anti-oxidant properties