Behçet’s disease is a chronic multisystem inflammatory disorder in which vascular involvement represents a major cause of morbidity and mortality. Although venous thrombosis is common, pulmonary embolism remains a rare and potentially life-threatening manifestation related to an inflammation-driven thrombotic mechanism. We report the case of a 70-year-old man with long-standing Behçet’s disease complicated by previous superior vena cava thrombosis, who was diagnosed with pulmonary embolism. Clinical presentation was nonspecific. Clinical probability assessment using the Wells and revised Geneva scores guided the diagnostic approach. Electrocardiographic findings were non-diagnostic, while transthoracic echocardiography allowed hemodynamic assessment and risk stratification. Computed tomography pulmonary angiography confirmed the diagnosis. This case underscores the diagnostic and therapeutic challenges of pulmonary embolism in Behçet’s disease and highlights the need for individualized management balancing immunosuppressive therapy and anticoagulation