Background: Type 2 diabetes mellitus (T2DM) is a major cardiovascular risk factor, yet echocardiographic data from the Jazan region of Saudi Arabia are scarce. Methods: This retrospective case-control study included Adults 168 patients with T2DM and 160 non-diabetic controls, (age- and gender are matched), who underwent transthoracic echocardiography at two hospitals in Jazan in period from (October 2024 to April 2026). Clinical, demographic, and echocardiographic data were retrieved from electronic medical records. Results: The results showed The results showed significant differences in echocardiographic measurements in DM and control group (IVSD/S/CM, IVIDS, LVIDS/CM, LVPWD/CM, ESV/ ML, %FS, AOD/ CM, AOR.AREA/CM², MV E/A ratio), P value <0.001, while insignificant differences in EDV/ ML, LV EF%, LAD/ CM among both groups (P value>0.05). insignificant correlation between HA1c and measurements in DM excepts for AOD (aortic diameter) and AOR.AREA/CM², P<0.05 Conclusion: Significant differences were noticed in myocardial function measurements among DM and control group, supported that the DM causes deterioration of myocardial function. Diabetic patients with abnormal findings exhibited larger IVS thickness and posterior wall thickness, indicating early concentric remodeling, while controls generally unveiled lower values.