Background: Vital pulp therapy aims to preserve pulp vitality following exposure, with calcium silicate-based materials such as Mineral Trioxide Aggregate (MTA) and Biodentine widely used for direct pulp capping. Their comparative clinical performance remains an area of ongoing research. Aim: To evaluate and compare the clinical and radiographic outcomes of Biodentine and MTA in direct pulp capping procedures. Materials and Methods: A prospective comparative study was conducted on 50 patients with mechanically exposed vital permanent teeth. Participants were randomly allocated into two groups: Group I (MTA, n=25) and Group II (Biodentine, n=25). Clinical parameters (postoperative pain using VAS, pulp vitality, tenderness) and radiographic outcomes (dentin bridge formation, periapical status) were assessed at 1, 3, and 6 months. Statistical analysis was performed using Chi-square test and independent t-test, with significance set at p<0.05. Results: Biodentine demonstrated significantly lower postoperative pain at 1 month (1.5 ± 0.9 vs 2.4 ± 1.2; p=0.03). Early dentin bridge formation at 3 months was significantly higher in the Biodentine group (84%) compared to MTA (68%) (p=0.04). At 6 months, dentin bridge formation was observed in 88% of Biodentine cases and 80% of MTA cases (p=0.39). Overall clinical success rates were comparable between the groups at 6 months (Biodentine: 92%; MTA: 88%; p=0.62). Conclusion: Biodentine showed superior early healing response with reduced postoperative pain and faster dentin bridge formation, while both materials demonstrated comparable long-term success. Biodentine can be considered an effective alternative to MTA for direct pulp capping.