Necrotizing fasciitis or "flesh-eating disease," is a rare and serious infection that can kill a person in less than a day. Early diagnosis and appropriate treatment can avoid serious complications that can lead to death. Herein, we report three cases of necrotizing fasciitis of the hand admitted to the emergency department and detail their management, from the diagnosis to the outcome. Before causing death, necrotizing fasciitis causes massive destruction of the soft tissue and bones, even in early diagnosed patients. The diagnosis is challenging, even for orthopedic surgeons. Once it is suspected, "acting fast" is mandatory, and so the orthopedic surgeon should be alerted.