Oral submucous fibrosis (OSMF) is a premalignant condition of insidious onset which affects the oral mucosa, pharynx, and oesophagus. Oral submucous fibrosis (OSMF) is a well-known precancerous oral lesion, characterized by scarring, tissue fibrosis, and premalignant lesions. The goal of clinical treatment is to reduce inflammation and improve patients' quality of life by enhancing mouth opening among others. The muscles of mastication are known to be affected resulting in limited mouth opening. Despite numerous therapeutic approaches, an ideal and universally accepted treatment modality remains elusive. Numerous treatment approaches for Oral Submucous Fibrosis exist, but there is limited robust evidence confirming their individual or collective effectiveness. While these treatments can alleviate the signs and symptoms of OSMF, a definitive cure remains elusive. This systematic review aims to assess and compare these various treatment modalities, focusing on their impact on clinical symptoms, functional outcomes, and disease progression. To achieve this, a comprehensive literature search was conducted across PUBMED, MEDLINE, EMBASE, and COCHRANE Library, limited to English-language publications. The search utilized incorporating the published literature till 2025 using the MeSH terms and keywords such as 'treatment modalities', 'Oral submucous fibrosis', ‘Mouth opening’, 'Diagnostic', and 'Therapeutic'. This review underscores the significance of habit control, physical therapy, intraoral appliances, as well as medicinal and surgical interventions in managing OSMF. Furthermore, it identifies areas where current knowledge is lacking, encouraging further research to develop more targeted therapies.