The purpose of the study was to determine the multiple physical training regimens on selected physical fitness variables among college men handball players. To attain the purpose sixty (N=60) Handball players studying various affiliated colleges in Alagappa University, Karaikudi, Tamil Nadu, India. Their age is between 17 and 21 years. The selected subjects were divided at random into four groups of fifteen each (n=15). Group-I underwent High-Intensity Interval Training (HIIT), Group-II underwent Functional Training (FT), Group-III underwent Combined High-Intensity Interval Training and Functional Training (HIITFT) and Group-IV acted as Control group(CG). Speed was selected as dependent variable and it was assessed by 50 meters run. The duration of the training period was restricted to eight weeks and number of sessions is five days per week. The data was collected prior to and immediately after the training period of eight weeks. The data obtained from the experimental groups before and after the experimental period were analyzed by using the statistical technique with depended ‘t’ test and Analysis of Covariance (ANCOVA). Whenever, the obtained ‘F’ ratio for the adjusted post-test was found to be significant the Scheffe's Post hoc test was used to access the paired mean differences. In all cases, 0.05 level is fixed as level of confidence to test the significance which is considered as appropriate. The results of the study observed that there is a notable difference among High-Intensity Interval Training (HIIT) group, Functional Training (FT) group, combined High-Intensity Interval Training (HIIT) and Functional Training (FT) group and Control group on Speed. Further the results of the study concluded that combined High-Intensity Interval Training (HIIT) and Functional Training (FT) group is better than groups on developing Speed.