Objectives: This study aimed to investigate the effect of battle rope and jump rope training combined with ladder drills on cardio respiratory endurance of college men students. Methods: The experimental study enrolled 45 college men students from Kumaraguru Institute of Agriculture, Erode, Tamil Nadu, who were selected to carry out the research. The subjects who met the inclusion criteria were selected using convenience sampling and randomly divided into two intervention groups. The test items used to collect the cardio respiratory endurance tested by Cooper 1.5-mile run test and for completed by the participants before the training intervention. The stipulated training was provided to the participants for the period of 50-minute sessions for the three alternative days in a week. Statistical Procedure: To process the results of the study, analysis of the data was done with the IBM SPSS Statistics 22 software. The statistics obtained were provided by paired sample t-test. The improvement percentage was assessed by using the formula of “%Δ = (x post-test – x pre-test) / pre-test * 100.” The level of confidence was fixed at 95% and values below p<0.05 were considered significant. Results: The paired sample t-test showed a significant (p<0.05) improvement in selected dependent variables over the 12 weeks of stipulated training. Conclusion: The results indicate considerable significant improvement on selected variable was observed. The findings indicate that both the training regimes led to significant improvement on the selected cardio respiratory endurance namely, Cooper test observation. The jump rope training combined with ladder drills has produced a superior effect compared to the battle rope training combined with ladder drills.