Nigerian economy is a multi-sector economy with agricultural and manufacturing sectors as the prime sectors. This study focused on the effect of commercial bank credits on the output of agricultural and manufacturing sectors in Nigeria. It spanned for the period of 31years (1986-2016) and made use of secondary data extracted from the Central Bank of Nigeria Statistical (CBN) Bulletin for various years. The study adopted ex-post facto research design and employed the Autoregressive Distributed Lag (ARDL) bound test and Ordinary least squares multiple regression analysis considering necessary diagnostic tests such as unit root test, test of normality, heteroskedasticity test, and cointegration test. The findings revealed that commercial bank credits have significant positive effect on the productivity of agricultural and manufacturing sectors in Nigeria. The implication of the findings is that more credits to agriculture and manufacturing sectors in Nigeria will increase output in the respective sectors. Hence, the researcher recommended among others more lending to agricultural and manufacturing sectors so as to boost productivity of these sectors.