This study focused on demonstrating the inhibitory activity of essential oils from four aromatic plants, Cymbopogon citratus, C. giganteus, Eucalyptus globulus, and Syzygium aromaticum, on strains of Candida albicans and Microsporum spp. in the Kisangani region. The essential oils were extracted by hydrodistillation and the antifungal activity was evaluated by aromatogram. The results revealed that, on the C. albicans strain, the average inhibition diameter was 3 mm for C. citratus essential oil, 1 mm for C. giganteus and E. globulus essential oils, and 24 mm for S. aromaticum essential oil. Furthermore, on the Microsporum spp. strain, the average inhibition diameter was 16 mm for C. citratus essential oil, 15.5 mm for C. giganteus essential oil, 8 mm for E. globulus essential oil, and 12 mm for S. aromaticum essential oil. This study shows that the inhibition diameters of the essential oils of the plant species studied have different activities on the two fungal strains (C. albicans and Microsporum spp.) tested. However, using Student's t-test, the probability obtained is p-value = 0.01, indicating a very significant difference in sensitivity between the two strains tested.