Introduction: Infertility affects about 15% of reproductive-age couples globally and is a highly stressful experience, especially for women facing psychological, social, and cultural impacts. Employment status may influence how women cope with infertility stress. Objective: To compare perceived mental stress levels between working and non-working infertile women attending selected infertility centres in Dhaka, Bangladesh, and to identify associated socio-demographic, reproductive, and social factors. Materials & Methods: This cross-sectional study from January to December 2022 was conducted at Mohammadpur Fertility Services and Training Center and BSMMU, Dhaka. It involved 110 infertile women (55 working, 55 non-working), aged 20-49, with primary infertility, selected via purposive sampling. Data were collected through face-to-face interviews with a pretested semi-structured questionnaire including the PSS-10. Height and weight were measured for BMI. SPSS v25 was used for analysis, employing descriptive stats, t-tests, chi-square, Fisher's exact tests, and regression, with p<0.05 as significant. Results: Working women had higher education (43.6% graduates vs 16.4%, p=0.001) and income (39,845 BDT vs 26,735 BDT, p=0.001), married later (22.16 vs 19.99 years, p=0.011), and shorter infertility duration (4.72 vs 6.05 years, p=0.022). Among working women, 61.8% had moderate stress and 36.4% low stress, while among non-working women, 89.1% had moderate stress and 7.3% had low stress (p=0.001). Marriage duration was linked to stress only among non-working women (p=0.031), with >5 years married experiencing higher stress. Caffeine intake correlated with stress only among non-working women (p=0.041). Social stigma was more common among non-working women (60.0% vs 49.1%). Conclusion: Non-working infertile women face higher moderate mental stress than working women. Employment acts as a protective factor via financial independence, social identity, and coping resources. Support services should target non-working women, who encounter greater social stigma, longer infertility duration, and fewer coping resources.