What is the economic impact of the African Growth and Opportunity Act (AGOA) on Ghana’s exports? Using a synthetic control method, a quasi- experimental approach, and a panel dataset for the periods 1965 through to 2018, this study examines the effects of AGOA on Ghana’s exports as a share of GDP. The findings show that AGOA has transitory positive effects in the initial stages but negative effects in the medium run. The positive impacts are largely attributed to sound macroeconomic environment and the discovery of oil while the negative impact is mostly due to the fall in US demands for exports from Africa in the wake of 2008-2009 financial crisis. AGOA does not automatically improve exports as a share of GDP of its member countries, which suggests the need for complementary government policies. However, the AGOA looks promising for Ghana if it is embarked by good policies.