On the palm are seen several angles known as ‘ATD’ angle, ‘DAT’ angle and ‘ADT’ angle. These angles are very useful medically. The aim of this study was to determining the palmar angles of down’s syndrome subjects in Nigeria. The study recruited 201 subjects, 101 Down syndrome subjects and 100 control subjects. The subjects were selected using a convenience sampling method from special and inclusive schools in Nigeria. Autocad program was used to measure the angles with high reliability. Data were collected and analysed using Mann Whitney U test. The results showed that Down syndrome had significantly higher ATD angle and significantly lower DAT and ADT angles when compared to control subjects. In conclusion, the result implies that Down syndrome showed high correlation with ATD, DAT ADT angles. These angles should serve an adjunct diagnostic tool for early screening and intervention of Down syndrome patients in Nigeria.