ATD angle is important dermatoglyphic trait that is being used for medical purposes. The study aimed at determining the ATD angle of autistic and control subjects in Nigeria. A total of 200 subjects was used, 100 autistic (82 males and 18 females) and 100 (65 males and 35 females) control subjects. The subjects were selected from various special schools in Nigeria using convenient sampling. Scanning method was used to collect the data. After that an Autocad software was used to measure the three tri-radii on the palm to get Atd angle. The data obtained were analysed using SSPS and Mann-Whitney U test was used to test for the results. The result showed a lower atd angle for autism than control subjects for both sexes and both hands and for females’ subjects. However, the left hand of male autistic subjects showed higher Atd angle when compared to the control subjects. The results revealed no significant difference between the Atd angle of autistic and control subjects (P>0.05) in Nigeria. Conclusively, the study deduced that ATD angle alone may not be enough in screening autism as it may not differentiate autism from control.