Background: Immunization during pregnancy, specifically with Tdap and Influenza vaccines, is vital for reducing maternal and neonatal morbidity and mortality. Despite global recommendations, vaccination coverage remains suboptimal due to knowledge gaps, safety concerns, and negative attitudes among expectant mothers. Aim: This review evaluates the current state of knowledge and attitudes regarding Tdap and Influenza vaccination among pregnant women and assesses the impact of educational interventions on vaccine uptake. Methods: A systematic literature search was conducted across PubMed, Cochrane, MEDLINE, and Google Scholar for peer-reviewed studies published between 2020 and 2024. The search utilized keywords related to pregnancy vaccination, Tdap, influenza, and educational interventions. A total of 27 studies (24 quantitative, 1 qualitative, and 2 mixed-methods) were included in the final synthesis. Results: Findings reveal significant global variations in vaccine awareness. Studies from Saudi Arabia, India, and China reported low levels of knowledge regarding vaccine safety and the benefits of maternal immunization. In contrast, European studies generally showed higher awareness, though misconceptions regarding fetal risks persisted. Across all regions, the primary barriers to vaccination included fear of side effects, lack of healthcare provider (HCP) recommendations, and misinformation. Conversely, educational interventions—including tailored mobile applications and provider-led health education—demonstrated a marked increase in vaccine acceptance and uptake post-intervention. Conclusion: Knowledge gaps and lack of HCP encouragement are critical barriers to maternal immunization. Structured educational interventions and strong provider-patient communication are essential strategies to demystify vaccinations and improve uptake. Future research should focus on longitudinal, culturally tailored interventional studies to develop effective public health campaigns.