Hemangioblastomas are sporadic tumors found in the cerebellum or spinal cord. Supratentorial hemangioblastoma are exceedingly rare tumors. We present a case of cerebral hemangioblastoma not associated with von Hippel-Lindau disease. A 35-year-old woman was admitted to a hospital with one mouth history of headache associated with partial seizures. Magnetic resonance imaging revealed a giant cystic mass occupying much of the right frontal hemisphere, with a hyperdense mural nodule. During surgery, the cyst was evacuated, and the mural nodule was completely excised. The postoperative course was uneventful. The histopathologic findings were considered consistent with hemangioblastoma. The finding of a cyst with a mural tumor nodule in the cerebral hemispheres suggests primarly a benign astrocytoma, but other tumors can present in a similar form. The treatment of choice for supratentorial hemangioblastoma is surgical resection. We report a case of supratentorial hemangioblastoma, review the literature, and discuss the radiopathological correlation and diagnostic difficulties associated with such lesions.