The main purpose of this study is to explore the mediating role of occupational health & safety standard relationship between organizational innovation and business performance. Secondly, in order to get achieve this core objective of predictor direct and indirect relationship estimate on business performance. Methodology in this study was constructed mainly on the basis of quantitative method, where quantitative research estimated of essential to recover the knowledge base and measurement of vital aspects regarding the characteristics of management tools into test the hypotheses. This study has conducted been by stratified random sampling in which data were collected from Bangladesh ready-made garment factories. Data has been collected by survey questionnaire instrument. The data used that obtained from primary sources of survey questionnaire method. There are three hypotheses have been developed through literature review that tested using through correlation and liner regression analysis executed by SPSS 20.v software. Findings-while execution of survey data the mediating impact of occupational health & safety standard, it was found that statistically significant and positive impacts on the relationship between organizational innovation and business performance improved. Both predictors are highly correlation of each other with business performance to the significant and positive relationships. Recommendations- Further studies including with other standards can combine together to test and verifying the structural equation model concerning of measurement model and structural model fits.