Introduction: Childhood disability represents a significant public health challenge in low-resource settings, yet detailed epidemiological profiles of children attending special education institutes in Bangladesh remain scarce. This study aimed to identify the pattern of disabilities and associated socio-demographic, perinatal, and familial characteristics among differently abled children attending Islami Bank Medical College and Hospital in Rajshahi, Bangladesh. Methods: A cross-sectional study was conducted among 120 children attending Islami Bank Medical College and Hospital in Rajshahi, Bangladesh. Data were collected via face-to-face interviews with mothers or guardians using a pre-tested, partially structured questionnaire. Disability types, birth history, maternal health, and familial factors were analyzed using descriptive statistics and chi-square tests in SPSS version 22. Result: The mean age of children was 8.85 (±4.25) years; 66.7% were male. Autism spectrum disorder was the most common disability (44.2%), followed by cerebral palsy (15.8%), Down syndrome (15.0%), and multiple disorders (13.3%). Half (50.8%) exhibited multiple co-occurring disability characteristics. Significant associations were found between disability type and sex (p<0.05), prematurity/low birth weight (p<0.001), birth trauma (p<0.001), and maternal age at conception (p<0.001). Despite 90.8% antenatal care coverage, 92.5% of mothers did not take folic acid during the first trimester, and 95.0% were unaware of micronutrient deficiencies. Conclusion: Autism is the predominant disability among children in this setting, with notable links to perinatal factors and maternal age. Critical gaps persist in maternal nutrition awareness and perinatal care. Findings underscore the need for targeted autism services, strengthened perinatal interventions, and integrated maternal health education to mitigate disability risks and improve outcomes for differently abled children in Bangladesh.