Pentylenetetrazole (PTZ) is a chemical convulsant that can generate seizure in humans and rodents which mirror the effects of naturally occurring pathological seizure disorders. This study aimed to investigate the role of methanolic extract of Tetrapleura tetraptera (METT) on neurological behavior and motor coordination in PTZ-induced epilepsy in male mice. A total of 50 mice were randomly assigned to 5 groups (n=10) as: Control (0.2ml saline orally); PTZ (single dose 35kg/mg s.c); Diazepam (1ml/100g-i.p) used as reference control; Low dose (LD: 400mg/kg) and High dose (HD: 800mg/kg) of METT was administered orally for 14 days after which PTZ (single dose, 35kg/mg s.c) was induced on the 22nd day. Seizure was confirmed using the Racine scale. Neurological test include; open field test (OFT) and social behavior test (recognition memory) and fine motor coordination using beam balance. These behavioral studies were performed 24 hours after the completion of the PTZ dose. OFT results showed that METT extract and diazepam significantly reduced locomotor activity (line crossing and rearing), but HD of METT suppresses line crossing better than diazepam. Centre square duration did not differ significantly, but METT extract and diazepam significantly reverse exploratory behavior (stretch attend posture and freezing duration). METT extracts was more potent than diazepam in ameliorating the abnormal social behavior posed by PTZ. Mice treated with diazepam and METT extract showed fine motor coordination which reduced the beam crossing time. METT may have anti-epileptic effect against PTZ-induced epilepsy in mice, and could be a better remedy than diazepam against epileptic seizures.