Background: The rising global prevalence of both metabolic syndrome (MetS) and thyroid nodules (TN) suggests a potential pathophysiological link. This study aimed to investigate the association between MetS and its individual components with the presence of thyroid nodules. Methods: A cross-sectional analytical pilot study was conducted over six months. A total of 70 participants (35 with benign TN and 35 without benign TN), aged 18-75 years, were enrolled via purposive sampling. MetS was diagnosed according to standard criteria requiring ≥3 of the following: elevated waist circumference, high blood pressure, impaired fasting glucose (IFG), high triglycerides, or low HDL-cholesterol. Anthropometric measurements, blood pressure, thyroid ultrasonography, and fasting blood samples for glucose, lipids, and thyroid function tests (TSH, FT3, FT4) were obtained. According to the exclusion criteria, cases with malignant thyroid nodules were resected. In this study, as thyroid nodules, only benign thyroid nodules were considered. Data were analyzed using unpaired t-tests, chi-square tests, and multiple logistic regression. Results: The prevalence of MetS was significantly higher in the nodule group compared to the control group (68.57% vs. 40.00%, p=0.001). Participants with nodules had significantly higher mean values for waist circumference, systolic and diastolic blood pressure, and fasting plasma glucose (all p<0.05). Low HDL-cholesterol (82.9% vs. 37.1%, p=0.046), high blood pressure (51.4% vs. 17.1%, p=0.005), and IFG (48.6% vs. 25.7%, p=0.004) were significantly more prevalent in the nodule group. Multiple logistic regression confirmed MetS (OR=5.00, 95% CI: 2.48-8.60, p=0.001), along with age, SBP, FT3, and FT4, as independent risk factors for TN. Conclusion: Metabolic syndrome and several of its components are significantly associated with an increased risk of thyroid nodules, suggesting that metabolic health may play a crucial role in thyroid nodule pathogenesis. The sample size was very small due to the COVID-19 situation.