This study assesses the level of attainment of SDGs 3 (Health), SDG 4 (Education), and SDG 6 (Clean Water and Sanitation) in Bui Division, North West Region of Cameroon. To attain the study objective and obtain meaningful results, a convenient methodology was used. The methodology involved a mixed-methods approach where data was collected through field surveys, stakeholder interviews, observations and analysis of secondary sources. Findings indicate that health services are constrained by inadequate health infrastructure and facilities, limited medical personnel, and insufficient access to essential medicines, resulting in suboptimal health outcomes. The education sector faces challenges including insufficient educational facilities, depreciated and destroyed school infrastructures, inadequate teaching materials and qualified teachers, insecurity and disparities in access, particularly in rural communities. Access to safe and potable water remains limited, with many populations relying on unimproved sources, increasing vulnerability to waterborne diseases. Despite these challenges, communities have implemented adaptive strategies such as local health initiatives, informal educational support, and community-based water management. These efforts demonstrate resilience and highlight the critical role of community participation in advancing development goals. The study concludes by recommending that achieving SDGs 3, 4, and 6 in Bui Division requires a multi-faceted approach that combines increased government investment, infrastructural development, capacity building, safe environment and community engagement. Leveraging local adaptation strategies alongside systemic interventions by stakeholders is essential to improving health, education, and water access, thereby enhancing overall quality of life. These findings provide valuable insights for policymakers, development practitioners, and researchers working in similar sub-national contexts.