Professional Roadside sweeping is associated with significant exposure to dust and vehicular emissions. Port Harcourt, the industrial and economic hub of Nigeria’s oil-rich Rivers State is a nidus for such environmental pollutants. Assessing the functionality of the cardiovascular and respiratory systems in such personnel will be quite revealing. Thus, this study assessed the cardiovascular and pulmonary functions of Professional Road Sweepers in Port Harcourt (PRS-PH). Using the multistage approach, including the purposive and snowball sampling techniques, the present study sampled a total of one hundred subjects (comprising 50 female road sweepers and 50 female non-road sweepers) who were within the ages of 18 and 60 years and residents of the area for five (5) years and above. Following standard methods, the digital spirometer was used to assess the lung functions (Forced Vital Capacity (PVC), Forced Expiratory Volume (FEV1), FVC/FEVI ratio) of Professional Road Sweepers in Port Harcourt Metropolis. The result indicated significant (p<0.05) difference in the blood pressures of the exposed group with respect to that of the unexposed group. The study revealed significantly (p<0.05) raised levels of Forced Vital Capacity (FVC), Forced Expiratory Volume in 1 second (FEV1), and FEV1/FVC ratio. This outcome is suggestive of a possible restrictive lung disorder in the road sweepers; In conclusion, the results of the study reveal a risk of cardiopulmonary disorders among the road sweepers. These findings will offer valuable insight and raise awareness and establish comprehensive measures that could protect these essential workers from cardiorespiratory hazards associated with their occupation.