Background: Pre-eclampsia is a hypertensive disorder of pregnancy associated with significant maternal and fetal morbidity. Identifying socio-demographic, obstetric, and biochemical risk factors is crucial for early detection and management. Objective: This study aimed to assess the socio-demographic profile and risk factors associated with pre-eclampsia at a tertiary care center in Bangladesh. Methods: This case-control study was conducted in the Department of Obstetrics and Gynecology, Institute of Child and Mother Health (ICMH), Dhaka, Bangladesh, from March 2023 to February 2024. In this study, A total of 70 pregnant women with a gestational age of 20–40 weeks, attending the Department of Obstetrics & Gynecology, ICMH, Dhaka, during the study period, were included in this study. Among them, 35 women diagnosed with pre-eclampsia were assigned as cases, and 35 normotensive pregnant women were taken as controls. Results: Most participants were aged 18–28 years, with no significant difference in mean age between cases (26.09 ± 5.39 years) and controls (24.94 ± 4.08 years; p = 0.321). Educational level and occupation were comparable between groups (p > 0.05). Mean parity, gravidity, and gestational age were also similar (p > 0.05). Serum CRP levels were significantly higher among cases (25.37 ± 14.70 mg/dL) than controls (4.22 ± 0.92 mg/dL; p < 0.001). Significant risk factors for pre-eclampsia included family history of hypertension (37.1% vs 14.3%; p = 0.030), obesity (BMI ≥ 27 kg/m², 45.7% vs 22.9%; p = 0.046), prior history of pre-eclampsia (17.1% vs 2.9%; p = 0.049), and elevated CRP (≥6 mg/dL, 80% vs 0%; p < 0.0001). Primigravidity showed borderline significance (57.1% vs 34.3%; p = 0.057). Conclusion: Elevated CRP, obesity, family history of hypertension, primigravidity, and prior pre-eclampsia are important risk factors for pre-eclampsia. Early identification of these factors may aid in risk stratification and timely intervention.