In Ngandajika (Democratic Republic of Congo), farmers still prefer to grow local varieties, accusing improved varieties of being susceptible to disease, demanding nutrients, and requiring excessive labor. They also criticize these varieties for having large rachises and few grains, requiring labor-intensive shelling, without considering several advantages offered by different improved varieties, such as earliness, yield, and the quality of by-products, including flour consistency. Local varieties are less productive (yield less than 1 ton of maize grain/ha) than improved varieties, whose production exceeds 1.9t/ha when manually weeded and hoeed three times, namely 15, 30, and 45 days after sowing. In the strategy to increase the yield of maize cultivation, the Musangana variety, which is one of the most cultivated varieties, was chosen and the impact of the frequency of manual weeding on the growth and dry grain yield of maize during the 2021-2022 growing season was evaluated; the trial was conducted in the open field at the MPOYI group under a Latin square design comprising four complete random blocks and comprising 4 elementary plots representing the experimental treatments. The treatments consisted of (T0) treatment not receiving weeding, (T1) treatment receiving weeding once, (T2) treatment receiving weeding twice and (T3) treatment receiving weeding three times. The results show a higher yield (1.9t/ha) of dry grains of maize with manual weeding having received weeding three times during the entire growing cycle, followed by 1.5t/ha obtained with those of manual weeding having received weeding twice during the entire growing cycle and 1.1t/ha with manual weeding having received weeding once during the growing cycle. The lowest average is 0.3t/ha on the manual weeding not having received weeding during the entire growing cycle.