Leather industry is a significant source of industrial wastewater pollution with effluent that is high in toxic metals like chromium (Cr), cadmium (Cd), lead (Pb), and iron (Fe). The contaminants are very dangerous to the environment and human health because of their toxicity, persistence and their potential to accumulate bio-accumulate. The research problem under study involves the creation of a magnesium oxide/zinc oxide (MgO/ZnO) nanocomposite that has a high selectivity in the removal of specific toxic metals in the tannery wastewater. A co-precipitation technique was used to produce the nanocomposite, which was then heated at 450oC to produce a crystalline material with improved surface properties. The successful formation of the nanocomposite and high surface reactivity of the nanocomposite were confirmed using characterization methods such as X-ray diffraction (XRD), Fourier-transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and Brunauer Bfer Emmett Teller surface area analysis. The experiments of batch adsorption were performed to determine the influence of the pH, contact time, dosage of adsorbent, and the initial concentration of metal on the efficiency of removal. Findings indicated that the MgO/ZnO nanocomposite had a high adsorption capacity, which reached high levels of toxic metals reduction under the conditions of optimal parameters. The data of adsorption were well-fitted with Langmuir and Freundlich isotherm models of adsorption, which showed monolayer and heterogeneous adsorption. These results indicate that MgO/ZnO nanocomposites could be used as an economical and sustainable substitute of the treatment of tannery wastewater, and has a possibility of large scale uses in industrial wastewater treatment.