Nature, people and civilization are timeless issues. The environmental field is currently dealing with a number of hot and time-sensitive concerns. In the current socioeconomic development situation in Vietnam, the Marxist perspective on the interaction between humans and nature is extremely methodologically significant. It not only provides us with a theoretical foundation for believing in human capabilities, but it also helps us identify a realistic way for humans to live in harmony and unity with nature during the development process. An Giang is a Mekong Delta province with a strong economic growth potential. Environmental protection still has significant limits that must be addressed as it grows. As a result, based on intriguing Marxist perspectives on the demonstrated relationship between persons, society, and nature, this paper suggests essential measures to foster economic integration while also protecting the natural environment in An Giang today.