A simple, Accurate, precise method was developed for the simultaneous estimation of the Abiraterone and Niraparib in syrup dosage form. Chromatogram was run through AgilentC18150 x 4.6 mm, 5m. Mobile phase containing 0.01N Potassium dihydrogen ortho phosphate: Methanol taken in the ratio 60:40was pumped through column at a flow rate of 1.0ml/min. Temperature was maintained at 30°C. Optimized wavelength selected was 260nm. A simple, Accurate, precise method was developed for the simultaneous estimation of the Abiraterone and Niraparib in tablet dosage form. Retention time of Abiraterone and Niraparib were found to be 2.185 min and 2.660 min. %RSD of the Abiraterone and Niraparib were and found to be 0.6 and 0.3 respectively. %Recovery was obtained as 99.09% and 99.60% for Abiraterone and Niraparib respectively. LOD, LOQ values obtained from regression equations of Abiraterone and Niraparib were 0.26, 0.80and 0.03, 0.08 respectively. Regression equation of Niraparib is y = 90785x + 1183.6 and y = 42063x + 50388 of Abiraterone. Retention times were decreased and run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.