Health status of the Pakistan population is growing aggravated. Incorporation of insalubrious regimen characterize by sedentary lifestyle, unhealthy intakes embracing tobacco products, soft drinks, junk food, mark as internal risk factors, accompanying the external exposures to air pollution, water contamination, ultra-violet radiation, garbage splaying characterizing insalubrious milieu, some of the sufficient cause for degenerative health status of population. Low conservation approach against these modifiable risk factors impel to frequent illnesses encounters which in absence of appropriate care mounting to serious conditions increase bombardment for secondary and tertiary care resulting high morbidity and mortality rate among masses. Article intends to highlight the frequent exposure to internal and external modifiable risk factors leading towards the escalated trends in incidence and prevalence of various acute and chronic diseases. Also embraces certain interventions likely to subdue insalubrious perils, trigger healthy regimen and signal positive outcomes in health status of the population. Article is based on literature review, formulated considering fact and figures, excerpted mostly of secondary sources. PubMed, DOIA browsed frequently to sieve most relevant content. Whole compilation phase has last for approximately 3 month dated June to August 2017.