The Labour Act 2003, Act 651 serves as guide to help foster a harmonious relationship between management and employees. It is paramount to acknowledge the significant role that Union activities have played. Amongst them are; bargaining on behalf of employees, bringing industrial harmony among employees and employers, serving as a guide and direction for employees to direct their grievances and many more. The study was to find out the impact of union activities on the performance of employees. The specific objectives of the study were: To identify the main strategies used by trade unions to protect the interest of members, to find out the benefits associated with joining trade unions and, to find out the effects of trade unions on workers performance. The significance of the study was to find out the socioeconomic good of workers at the Bawku Presbyterian Hospital and help unveil the problems associated with trade unions and its impact on their performance. The researchers through questionnaires used 70 respondents from the Bawku Presbyterian hospital who are members of Health Service Workers Union. Out of the findings 64% of the health workers said trade unions help workers to get their demands. The methodology used for the study was descriptive in nature. The findings of this study corroborate that of other researches that union activities have effect on workers performance at the workplace. Union activities have impact on the performance on work. This implies that it sounds appropriate for employers to put in place enough structure. Through that, industrial action will be reduced. Base on concrete satisfactory measures, it will be very difficult for workers to embark on strike action.