Sickle cell disease (SCD) remains a major global health burden characterized by chronic pain, inflammation, and psychosocial stress. While pharmacological approaches like hydroxyurea offer partial relief, integrative therapies including Ayurveda based sound and mantra therapy provide supportive, culturally appropriate options. This paper reviews the evidence and principles behind the use of sound healing, mantra chanting, and music-based interventions in SCD management, highlighting their roles in pain relief, stress reduction, emotional stability, and quality of life improvement.