This paper discussed on small and medium scale industries pathway to Nigeria economic development. It also point out the problems facing the entrepreneurship development of Nigeria economy. It also examines the importance of entrepreneurship in Nigeria. The methodology adopted was systematic review method. It also found that entrepreneurship can enhance economic development in Nigeria primarily by generating employment opportunity. The study also revealed that initiatives by government failed because of over bearing bureaucracies, corruption, inadequate and inefficient infrastructure facilities, financial backup and maladministration. The paper also recommended that government and banks should recognize the important entrepreneurship to her economic development growth by providing the enabling environment for small and medium scale industry to develop. Specifically, government should provide infrastructural facilities (electricity, road network, and communication). It is also recommended that government should reactivate all the institutions established to promote small and medium scale industries in Nigeria.