Background: Endometrial cancer (EC) is a leading gynecological malignancy worldwide, with rising incidence in developing countries. Prognostic factors play a critical role in guiding management, especially in resource-limited settings where molecular testing is not routinely available. Aim of the study: To evaluate clinicopathological prognostic factors influencing recurrence in patients with endometrial cancer treated at a tertiary care hospital in Bangladesh. Methods: A retrospective observational study was conducted on 45 histologically confirmed EC patients who underwent hysterectomy-based surgery. Demographic, clinical, pathological, and treatment-related data were analyzed using SPSS version 26.0. Univariate analysis was performed with Chi-square or Fisher’s exact test, and multivariate Cox regression was used to determine independent predictors of recurrence. Hazard ratios (HR) with 95% confidence intervals (CI) were reported, and a p-value <0.05 was considered statistically significant. Result: The mean age was 54.9±12.4 years; 55.6% were postmenopausal. Most patients presented with stage I disease (77.8%). Significant independent predictors of recurrence included tumor grade 3 (HR 2.75; p=0.039), myometrial invasion ≥50% (HR 3.80; p=0.023), LVSI presence (HR 4.25; p=0.007), advanced FIGO stage III–IV (HR 5.67; p=0.004), and lymph node positivity (HR 3.92; p=0.032). Surgical approach and adjuvant therapy were not significantly associated with recurrence. Conclusion: Advanced stage, high tumor grade, deep myometrial invasion, LVSI, and lymph node involvement are key prognostic factors for recurrence in EC. In low-resource settings, reliance on these clinicopathological predictors is essential for risk stratification and optimizing treatment strategies.