Background: Maxillectomy causes significant functional and esthetic impairments, affecting mastication, speech, and psychological well‑being. Prosthodontic rehabilitation improves oral health–related quality of life (QoL), but the influence of defect extent (Aramany classification) remains underexplored. Objective: To assess QoL outcomes in maxillectomy patients rehabilitated with obturator prostheses and compare variations across Aramany defect classes. Materials and Methods: A questionnaire‑based cross‑sectional study was conducted among 50 maxillectomy patients who underwent prosthodontic rehabilitation. QoL was evaluated using the Oral Health Impact Profile‑14 (OHIP‑14) and the Obturator Functioning Scale (OFS). Responses were recorded on Likert scales. Data were analyzed using SPSS v21.0 with Wilcoxon signed‑rank and chi‑square tests at a 5% significance level. Results: Males (58%) outnumbered females (42%). Most patients had Type I defects (52%), followed by Type II/III (14% each), Type IV (12%), and Type VI (8%). Mucormycosis was the leading cause (78%), followed by trauma (12%) and cancer (10%). Prosthodontic rehabilitation significantly improved QoL (p = 0.001). Patients with extensive anterior/posterior defects (Aramany I & II) showed lower functional and psychological domain scores than those with smaller lateral defects (Classes IV–VI). Post‑oncologic patients experienced greater psychological distress compared to trauma cases. Conclusion: Prosthodontic rehabilitation enhances QoL in maxillectomy patients, though outcomes vary based on Aramany defect classification and etiology. Personalized rehabilitation strategies considering defect size and etiology are essential.