This study investigates the impact of practical teaching methods on student performance in Introduction to Computing Sciences at the Federal University of Allied Health Sciences, Enugu. As digital literacy becomes a core requirement in health sciences, understanding how pedagogy influences foundational computing outcomes is essential. A quasi-experimental design was used to compare academic outcomes between two cohorts, one taught using conventional lecture methods and the other through hands-on, practical sessions involving lab exercises, simulations, and real-time projects. Data were collected using pre- and post-tests, performance assessments, and feedback surveys. Statistical analysis using paired and independent t-tests revealed a significant improvement in the experimental group’s performance (p < 0.05). Findings suggest that integrating practical, experiential approaches significantly enhances conceptual understanding, retention, and engagement in Computing Sciences. The study recommends institutional adoption of practical-based pedagogy to improve competence and academic success in computing courses, particularly for non-computer science majors in health-related disciplines.