Introduction: Raising and providing adequate facilities to the specially-abled children along with autism spectrum disorder is a very stressful and overwhelming task for their parents and caregivers. Most of the caregivers and parents of such children reported distress and hardships in caregiving because these children showed numerous difficulties. The difficulties and issues faced by the caregivers and parents in rearing children with autism is the principal focus of the present study. The current research study also highlighted the social support enhanced mental well-being of the caregivers. Children with autism experience innumerable problems related to their activities and behaviors. So, because of these problems, their caregivers face a lot of challenges in their normal day-to-day living and caregiving. Therefore, in these situations, social support is very crucial for them and it also enhances optimism in them to overcome their stress and also handle various issues related to caregiving efficiently and confidently. Objectives: The present research study intends to understand the role of perceived social support in facilitating optimism among the caregivers of children with autism, and also explore the relationship between perceived social support and optimism that may enhance the overall health and well-being of the caregivers of an autistic child. Method: Samples of sixty caregivers of children with autism spectrum disorder were taken for this study, using purposive sampling techniques. Life Orientation Test-Revised (LOT-R) for measuring optimism and Multidimensional Scale of Perceived Social Support (MPSS) was administered to measure perceived social support were employed. Pearson Product Moment Correlation Coefficient and Regression Analysis were used to analyze the results. Results: Positive and significant relationship was found between overall perceived social support and optimism, and perceived social support also facilitated optimism among the caregivers of children diagnosed with an autism spectrum disorder.