Background: The term toxoplasmosis is reserved to describe the clinical or pathological disease caused by Toxoplasma gondii and T. gondii infection for an asymptomatic primary infection or persistence of the parasite in tissues (chronic or latent infection). Objective: To evaluate the significance of detecting Toxoplasma gondii antigens in diagnosing and predicting the prognosis of acute toxoplasmosis, assessing its potential role in early intervention and treatment monitoring. Materials and Methods: The samples of the present study consisted of 39 women,31 of them infected with toxoplasmosis and 6 of them did not have toxoplasmosis, their age range was between (17-41) years, the blood samples were collected from Central Public health Laboratories (CPHL) in the period from (May 2022 to November 2022). Human Toxoplasma gondii ELISA kit is for the qualitative determination of Toxo-gondii in human serum. Results: The results of the present study showed in Table (1) since there were 26(96.3%) of housewife women had IgG Abs of T.gondii, while there was 1(3.7%) of employment women had IgG Abs of T.gondii , there were a significant differences between job categories and antibodies (IgG Abs) of T.gondii P=0.32. Conclusions: IgG Abs and IgM Abs of T.gondii presents more in housewife women than employment women. The Ag of T.gondii present in aborted women more than in non-aborted women. The Ag of T.gondii present more in women who had IgG Abs of T.gondii more than in women who had IgM Abs of T.gondii.