Ali ibn Isa Al-Kahhal, a medieval Muslim ophthalmologist, remains an underappreciated yet pivotal figure in medical history. His seminal treatise, Tadhkirat al-Kahhalin (The Notebook of the Oculists), is one of the earliest and most comprehensive works on ophthalmology, detailing ocular anatomy, pathology, and surgical techniques. This paper critically examines existing literature on Ali ibn Isa, analyzing his contributions, methodological approaches, and the factors contributing to his relative obscurity in modern historiography. The review highlights his systematic classification of over 130 eye diseases, including pioneering descriptions of cataracts, trachoma, and optic nerve disorders. His surgical innovations, such as the couching technique for cataract removal, were groundbreaking for their time and laid the foundation for future advancements. Moreover, his emphasis on empirical observation and case-based diagnosis anticipated modern clinical methodologies. Despite these achievements, Ali ibn Isa’s legacy has been largely overshadowed by figures like Ibn Sina and Al-Razi. His limited recognition stems from Eurocentric biases in medical history, the fragmentation of Arabic medical manuscripts, and the specialized nature of his work, which may have constrained its broader impact. By re-evaluating his contributions, this study underscores the necessity of integrating non-Western medical traditions into global medical historiography. This paper argues that Ali ibn Isa’s work deserves greater scholarly attention for its historical significance and role in transmitting medical knowledge across cultures and periods. A more inclusive reassessment of medical history offers a richer understanding of the diverse intellectual traditions that have shaped contemporary medical practice.