Taking cost-effective and efficient medical and wellness care at a beautiful location while enjoying a great vacation is profound as medical and wellness tourism. The medical and wellness tourism sector can play a decisive role in the growth of the economy, GDP, employment, and foreign exchange earnings of any country in the world. Unani medicine is one of the oldest traditional systems of medicine being practiced in many countries, including India, under the patronage of the Ministry of Ayush, Govt. of India. The principles of treatment employed in the Unani system are four-branched, which include dietotherapy, regimenal therapy, pharmacotherapy and surgery. Of them, the first three modes may be practically applied in the establishment of medical and wellness tourism centres in Unani medicine. Due to its holistic approach, this system of medicine has high potential for the treatment of many chronic ailments, viz., osteoarthritis, liver diseases, vitiligo, obesity, psychosomatic disorders, etc., to name a few, through its unique detoxification therapy called regimenal therapy. Various regimenal procedures, viz., cupping, hirudotherapy, irrigation therapy, etc.; many modified diets, like barley water, honey water, etc.; and certain special pharmacotherapeutics, such as munḍīj va mushil (concoctive & purgative) therapy and muqwaviyyāt (tonics), are useful for the treatment of various illnesses. Incorporation of these detoxification regimens, dietetics, and drug therapy may exert a significant influence on the outcomes of cosmeto-therapeutics, rejuvenation of mind, neuro-rehabilitation, etc. These are some of the core areas where the Unani system may play a stellar role in boosting medical tourism. Hence, the Ministry of Tourism in collaboration with the Ministry of Ayush may devise such ways and means to further strengthen the already existing Unani medical and wellness centres to attract foreign as well as domestic tourists for their healthcare issues.