Introduction: HIV infection is frequently responsible for a variety of digestive manifestations, both infectious and tumoral in origin. Upper GI endoscopy is a key diagnostic tool. Materials and methods: This study aims to describe the endoscopic aspects of upper digestive lesions in patients with HIV infection (PLHIV). Conducted between July 2017 and July 2024. Results: this study included 28 PLHIV patients who underwent oesophago-duodenal fibroscopy (FOGD) + Biopsies. The most frequently observed lesions were congestive gastritis (59.2%), mycotic esophagitis (25%) and erosive gastritis (22%). Histological study confirmed a predominance of chronic gastritis associated with Helicobacter pylori (77%). Conclusion: These results confirm the importance of endoscopy in the diagnosis and management of digestive complications of HIV.