Gout is a metabolic condition characterized by recurrent episodes of acute arthritis, primarily resulting from the deposition of monosodium urate crystals in and around the joints. Recognized as one of the oldest known diseases, it is referred to as Niqris in the Unani system of medicine. This system is based on the Hippocratic concept of the four humours (Akhlāṭ): Dam (blood), Balgham (phlegm), Ṣafrā’ (yellow bile), and Sawdā’(black bile). According to Unani medicine, such disorders arise from an imbalance of these humours, alteration in Mizāj’(temperament), and the accumulation of abnormal substances (Mawad-e-Fasida) in the joint spaces. Classical Unani physicians believed that Niqris typically affects individuals who have an excessive buildup of abnormal humours and are unable to eliminate them from the body. These retained substances settle in the joints, set off inflammatory responses marked by sharp pain, swelling, redness, and heat. This study aims to analyze the Unani perspective on the etiopathogenesis and clinical features of gout, as documented in classical texts, research articles, and manuscripts. The findings highlight the depth of Unani medical understanding and its potential role in guiding effective preventive and therapeutic strategies for the management of gout.