Oxidative stress is acknowledged as a significant contributor to the initiation and advancement of Diabetes Mellitus and its associated consequences. Consequently, antioxidant-based treatment approaches have garnered heightened interest in diabetes research. Detarium Senegalense (DS), a plant extensively used in traditional West African medicine, has antidiabetic and antioxidant characteristics. The present study therefore assessed and compared the antioxidant potential of fractionalized extracts of Detarium Senegalense in diabetic Wistar rat models. Male Wistar rats, with weights ranging from 150-200 grams, were deployed and randomly separated, with each of the 6 different groups having 7 rats per group. The first group took just water and ordinary feed (control), while groups 2-6 were subjected to streptozotocin (ST-Z) induction (60 mg/kg intraperitoneally). Group 2 was the control and received 60mg/kg streptozocin only intraperitonially, group 3 received ST-Z and 50mg/kg metformin (MET-F). Group 4, 5 and 6 received 250 mg/kg each of D. Senegalense (DS) extracts of ethyl acetate (DS_EA), N-hexane (DS_HE), and chloroform (DS_CE) respectively. Fasting blood glucose levels, Superoxide Dismutase (SOD), Malondialdehyde (MD-A), Catalase (CATL), were assessed and compared weekly over a 10-week period, before and after therapy. The experimental animals exhibited superior antioxidant bioactivity compared to control animals. Diabetic rats demonstrated a substantial elevation in MD-A, a depletion in CATL along with SOD. Administration of 250mg/kg each of hexane (DS_HE), ethyl acetate (DS_EA) as well as chloroform fractions (DS_CE) derived from the ethanol extract from the bark of the stem in conjunction with 50mg/kg of the anti-diabetic drug metformin (MET), substantially decreased MD-A levels while enhancing CATL and SOD, with the ethyl acetate extract demonstrating the greatest efficiency. The DS extract exhibited considerable antioxidant capabilities, substantiating its use in traditional medicine.