Operating room nursing interventions play a crucial role in ensuring patient safety and improving surgical outcomes. Surgical site infections (SSIs) remain a significant concern in perioperative care, leading to increased morbidity, extended hospital stays, and higher healthcare costs. The Review aimed to evaluate the Effectiveness of Operating room nursing interventions on Surgical site infection and patient outcomes. PubMed and CINAHL databases were searched, and research meeting criteria were included. Data were identified from all included articles, and themes were developed based on these data. PubMed and CINAHL databases were systematically searched for relevant studies published between 2018 and 2024. This scoping review synthesized evidence on the effectiveness of perioperative nursing interventions in reducing surgical site infections (SSIs) and improving patient outcomes. Thematic analysis was used to extract key intervention strategies, and a rigorous inclusion and exclusion process ensured the selection of high-quality studies. A total of 15 studies were included in the review. Findings indicated that implementing perioperative nursing interventions significantly reduced SSIs and enhanced patient recovery. Perioperative nursing interventions play a critical role in reducing SSIs and improving patient safety. Hospitals should integrate evidence-based nursing practices into surgical protocols to enhance infection prevention and optimize postoperative recovery.