Background: It is the duty of parents to ensure their children receive vaccinations. Consequently, the perspectives, understanding, and convictions of parents regarding vaccination play a vital role, as these factors affect their actions related to timely and complete immunization. Objectives: This systematic review thoroughly examined the latest literature concerning parents' awareness of children's vaccination in Arab nations. Methods: PubMed, SCOPUS, Web of Science, Science Direct, and Google Scholar were systematically searched to include the relevant literature. Rayyan QRCI was used throughout this systematic approach. Results & interpretation: This review encompassed fourteen studies involving a total of 13,082 parents, with 70.9% being mothers from Arab Countries. The level of knowledge regarding children's vaccinations among parents in Arab Countries was significantly influenced by factors such as the father's age, educational attainment, the employment status of mothers, and the type of family structure. It was observed that, Arab Countries, younger mothers exhibited a greater level of knowledge. Parents demonstrated a solid understanding and positive attitudes towards the seasonal influenza vaccine. However, while parents showed a reasonable level of knowledge about COVID-19 vaccinations, it was accompanied by some caution. Regarding HPV infection and vaccination, all participants reported low rates of vaccination and a limited willingness to vaccinate their children. Conclusion: The outcomes of this study underscore the importance of parental awareness concerning vaccinations and immunization in Arab Countries. Health authorities should intensify efforts to promote the advantages of vaccination while highlighting the dangers associated with delayed or missed pediatric immunizations.